Development of Selective DNA-Interacting Ligands

Understanding the Function of Non-canonical DNA Structures

Sefan Asamitsu


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This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases.  

Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity.   

This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.   

Détails
Auteur
Sefan  Asamitsu
Marque
Springer
Collection
Springer Theses
Parution
2020-09-16
Pages
111 pages
EAN papier
9789811577154
Langue
Anglais
Informations ebook
EAN PDF
9789811577161
Prix
94,94 €
En savoir plus
Nb pages copiables 1
Nb pages imprimables 11
Taille du fichier 6687 Ko
Ce livre est accessible aux handicaps   Informations sur l'accessibilité
EAN EPUB
9789811577161
Prix
94,94 €
En savoir plus
Nb pages copiables 1
Nb pages imprimables 11
Taille du fichier 33843 Ko
Ce livre est accessible aux handicaps   Informations sur l'accessibilité
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