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Filaggrin

Basic Science, Epidemiology, Clinical Aspects and Management

Howard I. Maibach, Jacob P. Thyssen

Springer
Date de publication : 2014-05-27

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Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

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Détails

Auteur

Howard I. Maibach , Jacob P. Thyssen

Marque

Springer

Collection

n.c

Parution

2014-05-27

Pages

373 pages

EAN papier

9783642543784

Langue

Anglais

Informations ebook

EAN EPUB

9783642543791

Prix

94,94 €

Nb pages copiables 3

Nb pages imprimables 37

Taille du fichier 4884 Ko

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Auteur(s) du livre

Howard I. Maibach

Jacob P. Thyssen

Jacob Thyssen has worked in Dermatology for 10 years and holds PhD and DmSci degrees from the University of Copenhagen. He has published 190 articles and 10 book chapters. He has received international awards for his research, including the LEO Pharma Research Foundation for best investigator <45 years in the Nordic countries. His research has focused on dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. He is a regular speaker at international meetings. Jacob Thyssen enjoys treating patients with dermatitis on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.

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