Trials for Cerebellar Ataxias

From Cellular Models to Human Therapies

Alexis Brice, Mario Manto, Stefan M. Pulst, Bing-Wen Soong

  • Springer

  • Date de publication : 2023-05-29

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Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias.  This book provides  a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress.  This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments.  The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials,  and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.

Détails
Auteur
Alexis  Brice , Mario  Manto , Stefan M.  Pulst , Bing-wen  Soong
Marque
Springer
Collection
n.c
Parution
2023-05-29
Pages
727 pages
EAN papier
9783031243448
Langue
Anglais
Informations ebook
EAN PDF
9783031243455
Prix
242,64 €
En savoir plus
Nb pages copiables 7
Nb pages imprimables 72
Taille du fichier 28908 Ko
Ce livre est accessible aux handicaps   Informations sur l'accessibilité
EAN EPUB
9783031243455
Prix
242,64 €
En savoir plus
Nb pages copiables 7
Nb pages imprimables 72
Taille du fichier 34744 Ko
Ce livre est accessible aux handicaps   Informations sur l'accessibilité
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Bing-wen Soong, MD, Ph.D.  is Professor in Neurology and Genetics (board-certified neurologist and geneticist, certified clinical trial investigator), Taipei Medical University and National Yang Ming Chiao Tung University Faculty of Medicine,  Taipei, Taiwan (Republic of China)

Mario Manto, MD, PhD, is the Head of the Department of Neurology at CHU-Charleroi in Belgium. He is also a Professeur de Neuroanatomie et Sémiologie Neurologique, Service des Neurosciences, at UMons, Mons, Belgium.

Alexis Brice, MD, Ph.D., is the Executive Director at the Paris Brain Institute in the ICM, Hôpital de la Pitié-Salpêtrière, Sorbonne Université  in France. 

Stefan-M. Pulst, M.D., Dr. med, is a Professor and  Chair in the Department of Neurology, at the University of Utah. 
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