Tous les ebooks de la collection "Ernst Schering Foundation Symposium Proceedings" - Springer

The Ubiquitin System in Health and Disease

Bernhard Haendler , Stefan Jentsch

Oncogenes Meet Metabolism

Collectif

In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance,...

Organocatalysis

Stefan Jaroch , Benjamin List , Manfred Reetz , Hilmar Weinmann

This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of...

Progestins and the Mammary Gland

Orla M. Conneely , Christiane Otto

Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers...

Sparking Signals

Gottfried Baier , Arne Bonin , Burkhart Schraven , Ulrich Zügel

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation,...

Cancer Stem Cells

Bernhard Haendler , D. Mumberg , Otmar D. Wiestler

Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current...

Immunotherapy in 2020

Khusru Asadullah , Wolf-Dietrich Döcke , Andreas Radbruch , Hans-Dieter Volk

This volume features contributions from participants of the ESRF symposium on Immunotherapy in 2020—Visions and Trends for Targeting Inflammatory Diseases held in Potsdam near Berlin, Germany, in October 2006. The symposium presentations covered the main mechanisms of...

New Avenues to Efficient Chemical Synthesis

T. Blume , P.H. Seeberger

In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged: Microreactor chemistry;...

Systems Biology

P. Bringmann , E. Butcher , G. Parry , B. Weiss

Systems biology has emerged as a highly interdisciplinary ?eld that has created broad enthusiasm in the scienti?c community.Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine. Developments are anticipated that will...

Chemical Genomics

Stefan Jaroch , Hilmar Weinmann

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the...

GPCRs: From Deorphanization to Lead Structure Identification

H. Bourne , Richard Horuk , J. Kuhnke , H. Michel

Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development....

Tissue-Specific Estrogen Action

Kenneth S. Korach , Tim Wintermantel

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology...