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Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Andrea Bonetti , Stephen B. Howell , Roberto Leone , Franco Muggia

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many...